Premature Trial Suspension Will Inevitably Alter Equipoise
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چکیده
منابع مشابه
Premature trial suspension will inevitably alter equipoise.
Premature Trial Suspension Will Inevitably Alter Equipoise To the Editor: The research report by the EVA-3S Investigators1 has implications which could far exceed their understandable desire to optimize safety within the trial. Following an early interim analysis, the investigators observed that the death/stroke rate after unprotected carotid angioplasty was 10.3% (6/58), as compared with 26.7%...
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The term “equipoise,” defined as “a state of equilibrium,” is a noun as well as a verb.[1] Clinical (or community) equipoise, which implies that there is uncertainty among the medical fraternity regarding the benefit, or otherwise, of a clinical intervention, provides the basis for conducting clinical trials.[2] Equipoise is also used as a guiding tool for patient–physician interactions, which ...
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“Do you have equipoise?” The question was simple, yet loaded with challenges. We were being invited to participate in a prospective randomized controlled phase 3 trial testing whether acute endovascular stroke therapy can be beneficial for patients presenting beyond 6 hours from symptom onset (≤6 hours is the currently accepted therapeutic time window for mechanical thrombectomy) when using per...
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ژورنال
عنوان ژورنال: Stroke
سال: 2004
ISSN: 0039-2499,1524-4628
DOI: 10.1161/01.str.0000127984.66352.a1